The cultivation of eucheumatoids started in the Philippines in 1960s and has since spread to many parts of the world. The traditional fixed, off-bottom monoline method which cannot adjust to abrupt changes in seawater conditions during low tides has compromised seaweed cultivars from increasing sea surface temperature. Ice-ice disease and epiphytes are twin maladies that brought down the production of eucheumatoids in recent years. Certain farms have collapsed at heights of hot dry months due to ice-ice disease and, in many cases, heavy infestations with epiphytes. Microbes induce ice-ice disease including bacteria and marine-derived fungi. Epiphytic filamentous algae like Polysiphonia-Neosiphonia complex heavily infested many seaweed farms in Zanzibar. Kappaphycus alvarezii, while observed to exhibit antimicrobial activity, also exhibits growth-promoting properties when tested with several bacterial strains. A model for seaweed-microbe pathosystem is proposed citing that while seaweeds have antimicrobial properties, under stressful environmental conditions, they can be overcome by opportunistic pathogens. Avoidance of maladies can mean a change in the farming practice, from off-bottom method to either floating line or raft method, and shifting the farming from shallow to deeper waters. In this era of warming seas farmers need to adopt to overcome the chronic problem of ice-ice and epiphytism.